Search This Blog

Sunday, January 18, 2009

scientists keep searching for new sources of drugs.

New Family Of Antibacterial Agents discovered
As bacteria resistant to commonly used antibiotics continue to increase in number, scientists keep searching for new sources of drugs. One potential new bactericide has now been found in the tiny freshwater animal Hydra.

The protein identified by Joachim Grötzinger, Thomas Bosch and colleagues at the University of Kiel, hydramacin-1, is unusual (and also clinically valuable) as it shares virtually no similarity with any other known antibacterial proteins except for two antimicrobials found in another ancient animal, the leech.
Hydramacin proved to be extremely effective though; in a series of laboratory experiments, this protein could kill a wide range of both Gram-positive and Gram-negative bacteria, including clinically-isolated drug-resistant strains like Klebsiella oxytoca (a common cause of nosocomial infections). Hydramacin works by sticking to the bacterial surface, promoting the clumping of nearby bacteria, then disrupting the bacterial membrane.
Grötzinger and his team also determined the 3-D shape of hydramacin-1, which revealed that it most closely resembled a superfamily of proteins found in scorpion venom; within this large group, they propose that hydramacin and the two leech proteins are members of a newly designated family called the macins.

1 comment:

123 said...

swiss watches even opened a new bazaar in Shanghai. I'm abiding they're counting on floods of consumers cloudburst in. Replica watches accept low price. This alarm is accessible in a bound copy of 5,007 pieces with a 45,5 mm case and a atramentous elastic strap. The punch has aswell a date affectation at 3 o’clock.

Find here

Home II Large Hadron Cillider News